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ITS » Paper and Presentation » Kimia - S2
Posted by tondoindra@gmail.com at 07/03/2016 11:06:38  •  960 Views


SINTESIS DAN SITOTOKSITAS 3-HIDROKSI-3-1H-INDOL-3-IL-5- NITROINDOLIN-2-ONA 3-HIDROKSI-5-NITRO-3- 1H-PIRROL-3-IL-INDOLIN-2-ONA 3-HIDROKSI- 3-1H-INDOL-3-IL-5-NITROINDOLIN-2-ONA TERHADAP SEL KANKER HATI HEPG2

SYNTHESIS AND CYTOTOXITY 3-HYDROXY-3-1H-INDOL-3-YL-5- NITROINDOLIN-2-ONE 3- HYDROXY -5-NITRO-3- 1H-PYRROL-3-YL-INDOLIN-2-ONE AND 3- HYDROXY -3-1H-INDOL-3-IL-5-NITROINDOLIN- 2-ONE AGAINTS LIVER CANCER CELL HepG2

Author :
KHANIFAH, FARACH ( 1411201701 )




ABSTRAK

kanker paru-paru. Pengobatan kanker hati pada khususnya dan kanker pada umumnya belum optimal sampai saat ini sehingga diperlukan pengembangan senyawa anti kanker baru. 33-di1H-indol-3-ilindolin-2-ona merupakan senyawa bahan alam yang menunjukkan aktifitas anti kanker hati HepG2 kolon dan payudara dengan masing-masing IC50 204 351 dan 498 956M sehingga senyawa-senyawa tersebut layak di kembangkan sebagai lead coumpound antikanker. Gugus pensubtitusi nitro diketahui meningkatkan bioaktivitas. Penelitian yang telah dilakukan berhasil mensintesis 3-hidroksi-3- 1H-indol-3-il-5-nitroindolin-2-ona reaksi 5-nitroisatin dengan indola dan 3- hidroksi-5-nitro-3-1H-pirrol-3-il-indolin-2-ona reaksi 5-nitroisatin dengan pirrola kedua reaksi dilakukan dengan katalis kalium bikarbonat dengan masingmasing rendemen 62 dan 76. 3-hidroksi-3-1H-indol-3-il-5-nitroindolin-2- ona diperoleh dari reaksi 5-nitroindolin-2-ona dengan pirrola dengan rendemen 80 dan reaksi 5-nitroindolin-2-ona dengan indola dengan rendemen 50. Kedua reaksi dilakukan dengan katalis Ceric Ammonium Nitrate CAN menggunakan gelombang ultrasonik. Uji sitotoksisitas menunjukkan bahwa ketiga hasil sintesis menunjukkan aktivitas antikanker hati HepG2. 3-1H-indol-3-il-5- nitro-3-1H-pirrol-2-ilindolin-2-ona lebih sitotoksik dibanding 3-hidroksi-5-nitro- 3-1H-pirrol-3-il-indolin-2-ona dan 3-hidroksi-3-1H-indol-3-il-5-nitroindolin-2- ona terhadap sel kanker hati HepG2 dengan masing-masing IC50 23786 39271 dan 46836 956M.


ABSTRACT

Liver cancer ranks second deadly type of cancer after lung cancer. The treatment of cancer of the liver in particular and cancer in general is not optimal until now so that required the development of the anti cancer new compound .33-di1H-indol-3-ilindolin-2-one Is a compound of nature that shows heart hepg2 anti cancer activity the colon and the breast with each IC50 204 351 dan 498 956M. So the compounds be developed as lead coumpound anticancer. A series of nitro improve bioaktivitas known The research that has been done successfully synthesize 3-hidroksi-3-1H-indol-3-il-5-nitroindolin-2-one from reaction 5- nitroisatin with indola. 3-hidroksi-5-nitro-3-1H-pirrol-3-il-indolin-2-one from reaction 5-nitroisatin with pirrola. The second reaction is performed with potassium bicarbonate catalyst with each yield 62 dan 76. 3-hidroksi-3-1Hindol- 3-il-5-nitroindolin-2-ona founded from reaction 5-nitroindolin-2-one with pyrrole yield 80 reaction 5-nitroindolin-2-one with indole yield 50. The second reaction is performed catalyst Ceric Ammonium Nitrate CAN and ultrasound wave. Cytotoxicity test results show that all three synthesis anticancer liver HepG2. 3-1H-indol-3-il-5-nitro-3-1H-pirrol-2-ilindolin-2-one more Cytotoxicity than 3-hidroksi-5-nitro-3-1H-pirrol-3-il-indolin-2-one and 3- hidroksi-3-1H-indol-3-il-5-nitroindolin-2-one terhadap cancer cell liver HepG2 each IC50 23786 39271 and 46836 956M.



Keywordssintesis, turunan isatin, indola, pirrola, sitotoksik, sel kanker hati HepG2
 
Subject:  Kanker
Contributor
  1. Prof. Mardi Santoso, Ph.D.
Date Create: 07/03/2016
Type: Text
Format: PDF
Language: Indonesian
Identifier: ITS-paper-14121150008625
Collection ID: 14121150008625
Call Number: RTKi 615.907 Kha s


Source
Paper And Presentation Of Chemistry RTKi 615.907 Kha s, 2016

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